Paroxysmal nocturnal haemoglobinuria (PNH) Program in Pharmaceutical Benefits Scheme (PBS) 012-22022230

PNH restriction and item codes

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$\\INTERNAL.DEPT.LOCAL\Shared\NAT\SERDELEXCEL\WORKPRODIMP\Operation Blueprint Migration\RDT Release Icons\32w\icon-hidden-attachment.png$ PBS PNH restriction and items codes

Eculizumab PNH dosing schedule for patients under 18 years

Table 1

Body weight	Induction phase	Maintenance phase
40kg and over	600mg weekly x 4 doses	900mg at week 5, then 900mg every 2 weeks
30kg to less than 40kg	600mg weekly x 2 doses	900mg at week 3, then 900mg every 2 weeks
20kg to less than 30kg	600mg weekly x 2 doses	600mg at week 3, then 600mg every 2 weeks
10kg to less than 20kg	600mg weekly x 1 dose	300mg at week 2, then 300mg every 2 weeks
5kg to less than 10kg	300mg weekly x 1 dose	300mg at week 2, then 300mg every 3 weeks

Ravulizumab PNH loading dose and vial calculator (adults only)

Table 2

Body weight	Loading dose	Number of 300mg vials	Number of 1100mg vials
40kg to less than 60kg	2400mg	8	0
60kg to less than 100kg	2700mg	9	0
100kg and over	3000mg	10	0

Ravulizumab PNH maintenance dose and vial calculator (adults only)

Table 3

Body weight	Maintenance phase	Number of 300mg vials	Number of 1100mg vials
40kg to less than 60kg	3000mg	10	0
60kg to less than 100kg	3300mg	0	3
100kg and over	3600mg	1	3

Ravulizumab PNH loading dose and vial calculator (paediatric patients who weigh <40kg)

Table 4

Body weight	Loading dose	Number of 300mg vials	Number of 1100mg vials
5kg to less than 10kg	600mg	2	0
10kg to less than 20kg	600mg	2	0
20kg to less than 30kg	900mg	3	0
30kg to less than 40kg	1200mg	4	0

Ravulizumab PNH maintenance dose and vial calculator (paediatric patients who weigh <40kg)

Table 5

Body weight	Maintenance phase	Number of 300mg vials	Number of 1100mg vials
5kg to less than 10kg	300mg	1	0
10kg to less than 20kg	600mg	2	0
20kg to less than 30kg	2100mg	7	0
30kg to less than 40kg	2700mg	9	0

Pegcetacoplan PNH dosing schedule (adults only)

Table 6: Pegcetacoplan 1080mg/20mL (54mg/mL) SC infusion

Dose	Frequency	Quantity
Recommended dose	1080mg (1 vial) twice weekly	8 or 9 vials per month
Dose adjustment (for patient LDH > 2*ULN )	1080mg (1 vial) every 3 days	10 vials per month