Atypical haemolytic uraemic syndrome (aHUS) Program in Pharmaceutical Benefits Scheme (PBS) 012-18051103

Atypical haemolytic uraemic syndrome (aHUS) restriction and item codes

Do not share this attachment externally. See Freedom of Information - Information Publication Scheme.

$\\INTERNAL.DEPT.LOCAL\Shared\NAT\SERDELEXCEL\WORKPRODIMP\Operation Blueprint Migration\RDT Release Icons\32w\icon-hidden-attachment.png$ atypical haemolytic uraemic syndrome restriction and item codes

Eculizumab

Repeats, weeks and days of treatment chart

Table 1

Repeats	Weeks	Days of treatment
0	4	28
1	8	56
2	12	84
3	16	112
4	20	140
5	24	168
6	28	196

aHUS dosing schedule for patients under 18 years

Table 2

Body weight	Induction phase	Maintenance phase
40 kg and over	900 mg weekly x 4 doses	1200 mg at week 5, then 1200 mg every 2 weeks
30 kg to less than 40 kg	600 mg weekly x 2 doses	900 mg at week 3, then 900 mg every 2 weeks
20 kg to less than 30 kg	600 mg weekly x 2 doses	600 mg at week 3, then 600 mg every 2 weeks
10 kg to less than 20 kg	600 mg weekly x 1 dose	300 mg at week 2, then 300 mg every 2 weeks
5 kg to less than 10 kg	300 mg weekly x 1 dose	300 mg at week 2, then 300 mg every 3 weeks

Ravulizumab

aHUS loading dose and vial calculator (adults and paediatric patients who weigh ≥ 40kg)

Table 3

Body weight	Loading dose	Number of 300mg vials	Number of 1100mg vials
40kg to less than 60kg	2400mg	8	0
60kg to less than 100kg	2700mg	9	0
100kg and over	3000mg	10	0

aHUS maintenance dose and vial calculator (adults and paediatric patients who weigh ≥ 40kg)

Table 4

Body weight	Maintenance phase	Number of 300mg vials	Number of 1100mg vials
40kg to less than 60kg	3000mg	10	0
60kg to less than 100kg	3300mg	0	3
100kg and over	3600mg	1	3

aHUS loading dose and vial calculator (paediatric patients who weigh < 40kg)

Table 5

Body weight	Loading dose	Number of 300mg vials	Number of 1100mg vials
5kg to less than 10kg	600mg	2	0
10kg to less than 20kg	600mg	2	0
20kg to less than 30kg	900mg	3	0
30kg to less than 40kg	1200mg	4	0

aHUS maintenance dose and vial calculator (paediatric patients who weigh < 40 kg)

Table 6

Body weight	Maintenance phase	Number of 300mg vials	Number of 1100mg vials
5kg to less than 10kg	300mg	1	0
10kg to less than 20kg	600mg	2	0
20kg to less than 30kg	2100mg	7	0
30kg to less than 40kg	2700mg	9	0

Contact details

PBS Complex Drugs Programs team

Forms

Atypical haemolytic uraemic syndrome (aHUS) - eculizumab initial or switching authority application (PB119)

Atypical haemolytic uraemic syndrome (aHUS) - ravulizumab - initial grandfather authority application (PB359)

Atypical haemolytic uraemic syndrome (aHUS) - eculizumab or ravulizumab - continuing authority application (PB125)

Atypical haemolytic uraemic syndrome (aHUS) - eculizumab or ravulizumab - recommencement authority application (PB176)

Services Australia website

Atypical haemolytic uraemic syndrome (aHUS)

External websites

PBS schedule for atypical haemolytic uraemic syndrome (aHUS)

Operational Information